City residents and tourists benefit from investments made by wealthy residents in the city's heyday, in arts and cultural institutions, and philanthropy also helped to establish a robust public library system in the city. More recent investments have provided the city with tourist attractions in the downtown area, such as Jacobs Field, the Rock and Roll Hall of Fame, and Playhouse Square Center. In studies conducted by The Economist in 2005, Cleveland and Pittsburgh were ranked as the most livable cities in the United States, and the city was ranked as the best city for business meetings in the continental U.S. Nevertheless, the city faces continuing challenges, in particular from concentrated poverty in some neighborhoods and difficulties in the funding and delivering of high-quality public education.

Neighborhoods:
Downtown Cleveland includes mixed-use neighborhoods such as the Flats and the Warehouse District, which are occupied by industrial and office buildings, and also by restaurants and bars. The number of downtown housing units in the form of condominiums, lofts, and apartments has increased over the past ten years.

Cleveland residents often define themselves in terms of whether they live on the east side or the west side of the Cuyahoga River. The east side comprises the following neighborhoods: Buckeye-Shaker Square, Central, Collinwood, Corlett, Euclid-Green, Fairfax, Forest Hills, Glenville, Payne/Goodrich-Kirtland Park, Hough, Kinsman, Lee Harvard/Seville-Miles, Mount Pleasant, Nottingham, St. Clair-Superior, Union-Miles Park, University Circle, Little Italy, and Woodland Hills. The west side of the city includes the following neighborhoods: Brooklyn Center, Clark-Fulton, Detroit-Shoreway, Cudell, Edgewater, Ohio City, Old Brooklyn, Stockyards, West Boulevard, and the four neighborhoods colloquially known as West Park: Kamm's Corners, Jefferson, Puritas-Longmead, and Riverside. Three neighborhoods in the Cuyahoga Valley are sometimes referred to as the south side: Industrial Valley/Duck Island, Slavic Village (North and South Broadway), and Tremont.

Several inner-city neighborhoods have begun to gentrify in recent years. Areas on both the west side (Ohio City, Tremont, and Edgewater) and the east side (Hough, Fairfax, and Little Italy) have been successful in attracting increasing numbers of artists, gays, and young professionals, which in turn is spurring new residential development. Furthermore, a live-work zoning overlay for the city's near east side has facilitated the transformation of old industrial buildings into loft spaces for artists.

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